Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDH2 All Species: 47.27
Human Site: T73 Identified Species: 80
UniProt: P40926 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40926 NP_005909.2 338 35503 T73 A D L S H I E T K A A V K G Y
Chimpanzee Pan troglodytes XP_001156205 338 35499 T73 A D L S H I E T K A A V K G Y
Rhesus Macaque Macaca mulatta XP_001114888 374 39932 T109 A D L S H I E T K A V V K G Y
Dog Lupus familis XP_849944 338 35431 T73 A D L S H I E T R A T V K G Y
Cat Felis silvestris
Mouse Mus musculus P08249 338 35593 T73 A D L S H I E T R A N V K G Y
Rat Rattus norvegicus P04636 338 35665 T73 A D L S H I E T R A N V K G Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415765 351 36949 T86 A D L S H I E T R A N V K G F
Frog Xenopus laevis NP_001085326 338 35691 T73 A D L S H I E T R A K V T G Y
Zebra Danio Brachydanio rerio NP_998296 337 35401 R73 D L S H I E T R A H V K G Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650696 336 35299 T73 A D L S H I D T K S K T A G F
Honey Bee Apis mellifera XP_392478 338 35783 T76 A D L S H M D T P A K V K A Y
Nematode Worm Caenorhab. elegans O02640 341 35101 S77 A D L S H I D S N A K V T A H
Sea Urchin Strong. purpuratus XP_792004 337 35239 T75 A D L S H I E T R A N V T G H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SN86 403 42387 T131 A D L S H C N T P S Q V R D F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 85.8 93.1 N.A. 94.9 94.3 N.A. N.A. 84.3 84 84.6 N.A. 58.8 65 56.8 68.3
Protein Similarity: 100 100 88.5 97 N.A. 98.2 97.9 N.A. N.A. 91.1 92 93.1 N.A. 76.3 80.7 72.7 83.1
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. N.A. 80 80 0 N.A. 60 66.6 53.3 73.3
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 0 N.A. 80 80 73.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. 50.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 63.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 93 0 0 0 0 0 0 0 8 79 15 0 8 15 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 93 0 0 0 0 22 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 0 0 0 8 65 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 22 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 8 72 0 % G
% His: 0 0 0 8 93 0 0 0 0 8 0 0 0 0 15 % H
% Ile: 0 0 0 0 8 79 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 29 0 29 8 58 0 0 % K
% Leu: 0 8 93 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 8 0 29 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 8 43 0 0 0 8 0 0 % R
% Ser: 0 0 8 93 0 0 0 8 0 15 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 8 86 0 0 8 8 22 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 15 86 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 58 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _